Acquity UPLC H-Class from Waters Corporation


HPLC familiarity with UPLC performance

If you are performing routine analyses or developing methods, or just prefer the flexibility of multi-solvent capabilities in a quaternary-based system, the only choice has been HPLC. Until now.

The ACQUITY UPLC H-Class is a streamlined system that brings together the flexibility and simplicity of quaternary solvent blending and a flow-through-needle injector to deliver the advanced performance expected of UPLC type separations – high resolution, sensitivity and improved throughput – while maintaining the robustness and reliability that ACQUITY systems are known for.

Choosing the ACQUITY UPLC H-Class enables you to continue running existing HPLC methods on a forward-looking LC platform that allows you to confidently and seamlessly transition to UPLC separations, when you’re ready, using integrated system tools and reliable column kits for method transfer and method development that simplify migration.

With the ACQUITY UPLC H-Class, your laboratory can achieve UPLC-quality separations without changing the way you work. The familiar design of the ACQUITY UPLC H-Class’s Quaternary Solvent Manager (QSM) and Sample Manager (SM-FTN), with flow-through needle design, gives you all the flexibility and usability of your current HPLC while still achieving the highly efficient separations that only UPLC can provide.


  • Multi-solvent blending: The QSM blends four solvents in any combination or proportion. Expand to up to nine solvent choices with the optional internal solvent-select valve for flexibility with methods.
  • Direct inject sampling: The needle-in-flow path of the SM-FTN delivers high-precision injections with excellent sample recovery, with specialized technology that ensures an accurate needle seal at high pressure.
  • Next-generation column compartments: Our new UPLC column heaters and managers are standardized with easy-to-access, low-volume, active solvent pre-heaters, resulting in the same efficiency system to system. Column pre-heaters ensure consistent thermal performance; column managers offer multi-zone flexibility with a temperature range of 4 to 90 °C, and are stackable.
  • Managed dwell volume: The ACQUITY UPLC H-Class’s patent-pending SmartStart Technology automatically manages gradient start time and pre-injection steps in parallel. By overlapping these typically serial processes, cycle time is minimized.

Related Video
Waters ACQUITY UPLC H-Class Overview

True UPLC performance with the highest resolution quaternary LC system. Improve characterization of complex samples, streamline your method development workflow, and future-proof your lab with the ability to support HPLC, UHPLC, and UPLC methods. (1:24)

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